Overweight individuals lack cells with satiety hormones
The mucous membrane of the upper gastrointestinal tract is home to highly specified cells, the so-called enteroendocrine cells, that constantly analyze our intestinal contents. During a meal, they release satiety hormones into the bloodstream. This signalizes to the body that enough food has been taken in and that the meal can be ended. The sense of satiation is created in the central nervous system. Tissue samples removed Compared to lean people, the release of satiety hormones is reduced in obese people. After bariatric surgeries, such as a gastric bypass or sleeve gastrectomy the release of these hormones increases again. Researchers from the Department of Biomedicine at the University and University Hospital Basel and the St. Claraspital Basel together with colleagues from the University of Liverpool have studied the reasons for this reduced release of satiety hormones. They examined tissue samples of the gastrointestinal tract in 24 lean volunteers and 30 obese patie...